The disease is characterized by left ventricular lv hypertrophy in the absence of another systemic or cardiac disease to account for the changes noted. An attempt should be made to detect the presence or absence of risk factors for sudden arrhythmic death. As a result, the heart cannot pump enough blood out to the body. Multiple factors have been incriminated in the etiology and progression of the myocardial damage. Hypertrophic cardiomyopathy hcm is the most common monogenic cardiovascular disorder, affecting one of every 500 adults. Cardiomyopathy free download as powerpoint presentation. Pdf cardiomyopathies are classified as either primary or.
A j marian jan 1, p 581 postulates that cardiac contractility is decreased in hypertrophic cardiomyopathy hcm and that the preserved or increased ejection fraction observed in patients with hcm is a result of the concentric nature of the hypertrophy. Hypertrophic cardiomyopathy characterised by myocardial hypertrophy,abnormal diastolic filling,intermittent ventricular outflow obstruction related to defects in force generation owing to altered sarcomeric function leading cause of lvh,unexplained by other clinicalpathologic cause caused by mutation of genes encoding sarcomeric proteins. The morphological expression of the intrinsic cardiomyopathies as seen in short axis cuts across the right and left ventricle at mid septal level. Marin predicts that study of young patients with familial hcm will reveal decreased myocyte contractility and postulates that insulinlike. Sherrid all patients with hypertrophic cardiomyopathy hcm should have five aspects of care addressed. Do you remember that cardiomyopathy is a disease of the heart muscle by the name, pathy meaning disease, cardio meaning heart, and myo meaning muscle, so disease of the heart muscle, so the first step in the. This article, the first in a twopart series, discusses the classification, pathophysiology and presentation of cardiomyopathies. Pathophysiology of dilated cardiomyopathy full text view.
Takotsubo cardiomyopathy tcm has gained global recognition as a unique cardiovascular disease that mimics acute myocardial infarction. Pathophysiology dilated cardiomyopathy pdf dilated cardiomyopathy is considered as the most common cause of chronic. Cardiomyopathy pathophysiology in 2006, the american heart association defined cardiomyopathies as. Deshmukh a, kumar g, pant s, rihal c, murugiah k, mehta jl. Listing a study does not mean it has been evaluated by the u. This site focused on cardiomyopathy in children and has information about the disease, caring for a child with cardiomyopathy, and tending to a child in the hospital. Pathophysiology and current therapy of congestive heart failure core. Cardiomyopathy denise antle, arnp, msn, ccrn, ccns critical care arnpcns genesis medical center davenport, iowa. Scroll down to read the article or download a printfriendly pdf here if the pdf fails to fully. Cardiomyopathy and anaesthesia bja education oxford. In cardiomyopathy, the heart muscle becomes enlarged, thick, or rigid. Dilated left ventricle with systolic dysfunction not caused by ischaemic or valvular heart disease cardiac dilatation with systolic dysfunction 3. Pdf left ventricular hypertrophy lvh is one of the most common cardiovascular diseases.
With hypertrophic cardiomyopathy, the heart muscle thickens. Myocarditis cardiomyopathy download ebook pdf, epub. Click download or read online button to get myocarditis cardiomyopathy book now. Lessons learned from the pediatric cardiomyopathy registry pcmr. Voiceover lets talk about the pathophysiology and diagnosis of dilated cardiomyopathy. Cardiomyopathy is a disease of the heart muscle that can be inherited or acquired and can affect people of all ages. After spending some time in practice and working as a house physician, she returned to glasgow as a resident in small animal clinical studies, majoring in cardiology, internal medicine and neurology.
Pathophysiology 03 cardiomyopathies flashcards quizlet. Drugs as possible triggers of takotsubo cardiomyopathy. It remains unclear why some patients are more prone to develop aicm despite similar arrhythmia burdens. Congenital heart disease represents only a small portion of patients presenting with congestive heart failure. Authorstask force members, elliott pm, anastasakis a, et al. Information on dilated cardiomyopathy, including diagnosis, symptoms and treatment.
Tachycardias, atrial fibrillation, and premature ventricular contractions are known to trigger a reversible dilated cardiomyopathy referred as arrhythmiainduced cardiomyopathy aicm. If you break down the word cardiomyopathy you can remember that its a disease of the heart muscle because cardio stands for. Basic scientists are elucidating the pathogenesis and. It is found across all racial groups and is the most common cause of sudden death in young athletes. Arrhythmias coexist in patients with heart failure hf and left ventricular lv dysfunction. With restrictive cardiomyopathy, the heart muscle becomes hard and stiff. Types of cardiomyopathy with dilated cardiomyopathy, the heart thins and enlarges. Pathophysiology dilated cardiomyopathy pdf download. The term alcoholic cardiomyopathy acm has been widely used to describe a specific heart muscle disease found in individuals with a history of longterm heavy alcohol ethanol consumption. Cardiomyopathies circulation research aha journals. Dilated cardiomyopathy has many known and probably many unidentified causes see table causes of dilated cardiomyopathy. More than 20 viruses can cause dilated cardiomyopathy. Congestive cardiomyopathy is a clinical state in which an abnormality of ventricular myocardium results in impaired pump function and circulatory congestion.
The healthcare implications of the obesity epidemic are profound. Dilated cardiomyopathy also called idiopathic dilated cardiomyopathy is a condition in which the heart becomes weak and the chambers get large. Pdf the pathophysiology of cardiac hypertrophy and heart failure. However, the pathophysiological explanation behind its. Dilated cardiomyopathy cardiovascular disorders msd. Pathophysiology of dilated cardiomyopathy the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Hypertrophic cardiomyopathy hcm is a condition in which the heart muscle becomes thick. These diseases have many causes, signs and symptoms, and treatments. Scroll down to read the article or download a printfriendly pdf here. Understanding the progression of dilated cardiomyopathy will be critical in the design of treatment modalities to intervene at the molecular level in the initial stages of pathogenesis. In the uk, the estimated incidence of cardiomyopathy is 1 in 500. The disorder is characterized by diverse phenotypic. Do you remember that cardiomyopathy is a disease of the heart muscle by the name, pathy meaning disease, cardio meaning heart, and myo meaning muscle, so disease of the heart muscle, so the first step in the pathogenesis of hypertrophic cardiomyopathy is that you have a problem with the heart muscle, and in hypertrophic cardiomyopathy. Hypertrophic cardiomyopathy is defined as an enlarged heart with hypertrophic myocardial walls 1,35 fig.
Wellestablished and new techniques of cardiac imaging are also helpful in this regard. Etiology and panduan ramadhan pdf pathogenesis of dilated cardiomyopathy. Discuss the pathophysiology and etiologies of dilated. Cardiomyopathy affects the shape, function, and electrical system of the heart. Joanna dukes mcewan graduated from glasgow in 1986. Pathophysiology and evolution of the clinical syndrome obesity produces an increase in total blood volume and cardiac output because of the high metabolic. Since it was first described 20 years ago in japan, takotsubo cardiomyopathy has received considerable interest from the medical community around the world, particularly in recent years. This site is like a library, use search box in the widget to get ebook that you want. Since its initial description, more than three decades ago, we have significantly advanced our understanding of diagnosing, treating, and prognosticating this reversible cardiovascular phenomenon.
Pathophysiology and treatment of hypertrophic cardiomyopathy mark v. Cardiomyopathies are classified traditionally according to morphological and functional criteria into four categories. Persons with cardiomyopathy frequently retain excess fluid, resulting in congestion of the lungs, and have. Although takotsubo cardiomyopathy was originally described as a transient, stressinduced dysfunction of the left ventricular apex, other morphological subtypes have now been described. Pathophysiology and evolution of the clinical syndrome. Pathophysiology of hypertrophic cardiomyopathy the lancet. Fetal hypertrophic cardiomyopathy is a heterogeneous condition that can be primary or secondary to extrinsic factors. Cardiomyopathy, any cardiac disease process that results in heart failure due to a decrease in the pumping power of the heart or due to an impairment in the filling of the cardiac chambers. Peripartum cardiomyopathy ppcm is a rare, often dilated, cardiomyopathy with systolic dysfunction that presents in late pregnancy or, more commonly, the early postpartum period. Coronary artery disease is the leading cause of death with overall mortality of approximately 245 per 100 000 individuals in 2008. The pediatric cardiomyopathy registry and heart failure.
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